Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines
Identifieur interne : 004768 ( Main/Exploration ); précédent : 004767; suivant : 004769Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines
Auteurs : D. Hannani [France] ; C. Locher [France] ; T. Yamazaki [France] ; V. Colin-Minard [France] ; M. Vetizou [France] ; L. Aymeric [France] ; S. Viaud [France] ; D. Sanchez [République tchèque] ; M J Smyth [Australie] ; P. Bruhns [France] ; G. Kroemer [France] ; L. Zitvogel [France]Source :
- Cell Death and Differentiation [ 1350-9047 ] ; 2013.
Abstract
Immunogenic cell death induced by cytotoxic compounds contributes to the success of selected chemotherapies by eliciting a protective anticancer immune response, which is mediated by CD4+ and CD8+ T cells producing interferon-
Url:
DOI: 10.1038/cdd.2013.60
PubMed: 23744294
PubMed Central: 3857618
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000040
- to stream Pmc, to step Curation: 000040
- to stream Pmc, to step Checkpoint: 001B90
- to stream Ncbi, to step Merge: 001296
- to stream Ncbi, to step Curation: 001296
- to stream Ncbi, to step Checkpoint: 001296
- to stream Main, to step Merge: 004884
- to stream Main, to step Curation: 004768
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines</title>
<author><name sortKey="Hannani, D" sort="Hannani, D" uniqKey="Hannani D" first="D" last="Hannani">D. Hannani</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Locher, C" sort="Locher, C" uniqKey="Locher C" first="C" last="Locher">C. Locher</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yamazaki, T" sort="Yamazaki, T" uniqKey="Yamazaki T" first="T" last="Yamazaki">T. Yamazaki</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Colin Minard, V" sort="Colin Minard, V" uniqKey="Colin Minard V" first="V" last="Colin-Minard">V. Colin-Minard</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Pediatric and Adolescent Oncology</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vetizou, M" sort="Vetizou, M" uniqKey="Vetizou M" first="M" last="Vetizou">M. Vetizou</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aymeric, L" sort="Aymeric, L" uniqKey="Aymeric L" first="L" last="Aymeric">L. Aymeric</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Viaud, S" sort="Viaud, S" uniqKey="Viaud S" first="S" last="Viaud">S. Viaud</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sanchez, D" sort="Sanchez, D" uniqKey="Sanchez D" first="D" last="Sanchez">D. Sanchez</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic</institution>
, Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smyth, M J" sort="Smyth, M J" uniqKey="Smyth M" first="M J" last="Smyth">M J Smyth</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Queensland Institute of Medical Research</institution>
, Herston, 4006, Queensland,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>School of Medicine, The University of Queensland</institution>
, Brisbane, QLD 4072, Queensland,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruhns, P" sort="Bruhns, P" uniqKey="Bruhns P" first="P" last="Bruhns">P. Bruhns</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Institut Pasteur, Département d'Immunologie, Laboratoire Anticorps en Thérapie et Pathologie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U760</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>INSERM U848</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Sorbonne Paris Cité, University of Paris Descartes</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Equipe 11 labellisée Ligue contre le Cancer, Centre de recherche des Cordeliers</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zitvogel, L" sort="Zitvogel, L" uniqKey="Zitvogel L" first="L" last="Zitvogel">L. Zitvogel</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Center of clinical Investigations in Biotherapies of Cancer (CICBT)</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23744294</idno>
<idno type="pmc">3857618</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857618</idno>
<idno type="RBID">PMC:3857618</idno>
<idno type="doi">10.1038/cdd.2013.60</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000040</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000040</idno>
<idno type="wicri:Area/Pmc/Curation">000040</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000040</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001B90</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001B90</idno>
<idno type="wicri:Area/Ncbi/Merge">001296</idno>
<idno type="wicri:Area/Ncbi/Curation">001296</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001296</idno>
<idno type="wicri:doubleKey">1350-9047:2013:Hannani D:contribution:of:humoral</idno>
<idno type="wicri:Area/Main/Merge">004884</idno>
<idno type="wicri:Area/Main/Curation">004768</idno>
<idno type="wicri:Area/Main/Exploration">004768</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines</title>
<author><name sortKey="Hannani, D" sort="Hannani, D" uniqKey="Hannani D" first="D" last="Hannani">D. Hannani</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Locher, C" sort="Locher, C" uniqKey="Locher C" first="C" last="Locher">C. Locher</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yamazaki, T" sort="Yamazaki, T" uniqKey="Yamazaki T" first="T" last="Yamazaki">T. Yamazaki</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Colin Minard, V" sort="Colin Minard, V" uniqKey="Colin Minard V" first="V" last="Colin-Minard">V. Colin-Minard</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Pediatric and Adolescent Oncology</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vetizou, M" sort="Vetizou, M" uniqKey="Vetizou M" first="M" last="Vetizou">M. Vetizou</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aymeric, L" sort="Aymeric, L" uniqKey="Aymeric L" first="L" last="Aymeric">L. Aymeric</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Viaud, S" sort="Viaud, S" uniqKey="Viaud S" first="S" last="Viaud">S. Viaud</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sanchez, D" sort="Sanchez, D" uniqKey="Sanchez D" first="D" last="Sanchez">D. Sanchez</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic</institution>
, Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smyth, M J" sort="Smyth, M J" uniqKey="Smyth M" first="M J" last="Smyth">M J Smyth</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Queensland Institute of Medical Research</institution>
, Herston, 4006, Queensland,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>School of Medicine, The University of Queensland</institution>
, Brisbane, QLD 4072, Queensland,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruhns, P" sort="Bruhns, P" uniqKey="Bruhns P" first="P" last="Bruhns">P. Bruhns</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Institut Pasteur, Département d'Immunologie, Laboratoire Anticorps en Thérapie et Pathologie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U760</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>INSERM U848</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Sorbonne Paris Cité, University of Paris Descartes</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Equipe 11 labellisée Ligue contre le Cancer, Centre de recherche des Cordeliers</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zitvogel, L" sort="Zitvogel, L" uniqKey="Zitvogel L" first="L" last="Zitvogel">L. Zitvogel</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INSERM U1015, Equipe labellisée Ligue contre le Cancer</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Cancérologie Gustave Roussy</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>University of Paris Sud XI</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Center of clinical Investigations in Biotherapies of Cancer (CICBT)</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell Death and Differentiation</title>
<idno type="ISSN">1350-9047</idno>
<idno type="eISSN">1476-5403</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Immunogenic cell death induced by cytotoxic compounds contributes to the success of selected chemotherapies by eliciting a protective anticancer immune response, which is mediated by CD4<sup>+</sup>
and CD8<sup>+</sup>
T cells producing interferon-<italic>γ</italic>
. In many instances, cancer progression is associated with high titers of tumor-specific antibodies, which become detectable in the serum, but whose functional relevance is elusive. Here, we explored the role of humoral immune responses in the anticancer efficacy of anthracyclines. Chemotherapy reduced the number of tumor-infiltrating B cells, and failed to promote humoral responses against immunodominant tumor antigens. Although anthracycline-based anticancer chemotherapies failed in T cell-deficient mice, they successfully reduced the growth of cancers developing in mice lacking B lymphocytes (due to the injection of a B-cell-depleting anti-CD20 antibody), immunoglobulins (Igs) or Ig receptors (Fc receptor) due to genetic manipulations. These results suggest that the humoral arm of antitumor immunity is dispensable for the immune-dependent therapeutic effect of anthracyclines against mouse sarcoma. In addition, we show here that the titers of IgA and IgG antibodies directed against an autoantigen appearing at the cell surface of tumor cells post chemotherapy (calreticulin, CRT) did not significantly increase in patients treated with anthracyclines, and that anti-CRT antibodies had no prognostic or predictive significance. Collectively, our data indicate that humoral anticancer immune responses differ from cellular responses in, thus far, that they do not contribute to the success of anthracycline-mediated anticancer therapies in human breast cancers and mouse sarcomas.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>République tchèque</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Hannani, D" sort="Hannani, D" uniqKey="Hannani D" first="D" last="Hannani">D. Hannani</name>
</noRegion>
<name sortKey="Aymeric, L" sort="Aymeric, L" uniqKey="Aymeric L" first="L" last="Aymeric">L. Aymeric</name>
<name sortKey="Aymeric, L" sort="Aymeric, L" uniqKey="Aymeric L" first="L" last="Aymeric">L. Aymeric</name>
<name sortKey="Aymeric, L" sort="Aymeric, L" uniqKey="Aymeric L" first="L" last="Aymeric">L. Aymeric</name>
<name sortKey="Bruhns, P" sort="Bruhns, P" uniqKey="Bruhns P" first="P" last="Bruhns">P. Bruhns</name>
<name sortKey="Bruhns, P" sort="Bruhns, P" uniqKey="Bruhns P" first="P" last="Bruhns">P. Bruhns</name>
<name sortKey="Colin Minard, V" sort="Colin Minard, V" uniqKey="Colin Minard V" first="V" last="Colin-Minard">V. Colin-Minard</name>
<name sortKey="Colin Minard, V" sort="Colin Minard, V" uniqKey="Colin Minard V" first="V" last="Colin-Minard">V. Colin-Minard</name>
<name sortKey="Hannani, D" sort="Hannani, D" uniqKey="Hannani D" first="D" last="Hannani">D. Hannani</name>
<name sortKey="Hannani, D" sort="Hannani, D" uniqKey="Hannani D" first="D" last="Hannani">D. Hannani</name>
<name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name>
<name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name>
<name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name>
<name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name>
<name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name>
<name sortKey="Locher, C" sort="Locher, C" uniqKey="Locher C" first="C" last="Locher">C. Locher</name>
<name sortKey="Locher, C" sort="Locher, C" uniqKey="Locher C" first="C" last="Locher">C. Locher</name>
<name sortKey="Locher, C" sort="Locher, C" uniqKey="Locher C" first="C" last="Locher">C. Locher</name>
<name sortKey="Vetizou, M" sort="Vetizou, M" uniqKey="Vetizou M" first="M" last="Vetizou">M. Vetizou</name>
<name sortKey="Vetizou, M" sort="Vetizou, M" uniqKey="Vetizou M" first="M" last="Vetizou">M. Vetizou</name>
<name sortKey="Vetizou, M" sort="Vetizou, M" uniqKey="Vetizou M" first="M" last="Vetizou">M. Vetizou</name>
<name sortKey="Viaud, S" sort="Viaud, S" uniqKey="Viaud S" first="S" last="Viaud">S. Viaud</name>
<name sortKey="Viaud, S" sort="Viaud, S" uniqKey="Viaud S" first="S" last="Viaud">S. Viaud</name>
<name sortKey="Viaud, S" sort="Viaud, S" uniqKey="Viaud S" first="S" last="Viaud">S. Viaud</name>
<name sortKey="Yamazaki, T" sort="Yamazaki, T" uniqKey="Yamazaki T" first="T" last="Yamazaki">T. Yamazaki</name>
<name sortKey="Yamazaki, T" sort="Yamazaki, T" uniqKey="Yamazaki T" first="T" last="Yamazaki">T. Yamazaki</name>
<name sortKey="Yamazaki, T" sort="Yamazaki, T" uniqKey="Yamazaki T" first="T" last="Yamazaki">T. Yamazaki</name>
<name sortKey="Zitvogel, L" sort="Zitvogel, L" uniqKey="Zitvogel L" first="L" last="Zitvogel">L. Zitvogel</name>
<name sortKey="Zitvogel, L" sort="Zitvogel, L" uniqKey="Zitvogel L" first="L" last="Zitvogel">L. Zitvogel</name>
<name sortKey="Zitvogel, L" sort="Zitvogel, L" uniqKey="Zitvogel L" first="L" last="Zitvogel">L. Zitvogel</name>
<name sortKey="Zitvogel, L" sort="Zitvogel, L" uniqKey="Zitvogel L" first="L" last="Zitvogel">L. Zitvogel</name>
</country>
<country name="République tchèque"><noRegion><name sortKey="Sanchez, D" sort="Sanchez, D" uniqKey="Sanchez D" first="D" last="Sanchez">D. Sanchez</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Smyth, M J" sort="Smyth, M J" uniqKey="Smyth M" first="M J" last="Smyth">M J Smyth</name>
</noRegion>
<name sortKey="Smyth, M J" sort="Smyth, M J" uniqKey="Smyth M" first="M J" last="Smyth">M J Smyth</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004768 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004768 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3857618 |texte= Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23744294" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |